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doi:10.1016/j.jhep.2017.07.005

In a study using an OVA-induced AR mouse model, N,N -dicoumarolespermidine reduced serum OVA-specific IgE production and the abundance of inflammatory cells in nasal lavage fluid

Besides, the protective effect of berberine resisting MTPT-induced toxicity may be related to the enhancement of autophagy by berberine through AMPK-dependent pathways ( The study found that berberine alleviated the severity of symptoms in the multiple sclerosis mouse model, and in primary astrocyte culture, berberine inhibited the increase in sphingosine kinase-1 (SphK1), and Sphingosine-1-phosphate (S1P) induced by lipopolysaccharide

In contrast, the triangle domain (and the full-length protein) is pulled-down by your protein of interest so they co-elute