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Ipamorelin activates gastric ghrelin receptors, which can promote gastrointestinal peristalsis and secretion of digestive fluids, increasing patients' appetite
Note that semaglutide is very similar to GLP-1 and its mechanism of action is therefore limited to the activation of the receptor for this hormone, while tirzepatide is made up of an amalgam of amino acids found both in the GLP-1 (yellow circles), GIP (blue circles), and in the two hormones (green circles), which gives it a double agonist activity, capable of activating both receptors for these hormones
A 2025 study comparing the GLP-1 pill with the GLP-1 injection found their effectiveness for lowering blood sugar and aiding weight loss in adults with type 2 diabetes were comparable
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