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Lymphatic drainage plays a vital role in managing lipedema by improving lymph flow and reducing swelling

31,32 In diabetic peripheral neuropathy (DPN), macrophages infiltrate to initiate repairment on nerve injury, with more cytokine and chemokine released

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37 However, different studies showed that MAPK pathways phosphorylate PPAR and reduce its transcriptional activity and that activation of MAPK antagonizes 3T3-L1 adipocytic differentiation