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Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite
In particular, in comparison with those who have a low proportion of MMA (III + V) in urine, those who have a higher proportion have been observed to be at higher risks for heart disease, atherosclerosis, peripheral vascular disease, hypertension, and bladder, lung, and skin cancer (reviewed in Steinmaus et al
Side effects are generally mild and tend to diminish over time
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