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Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1
It is shown that IGFBP1 expression and secretion were significantly elevated in cancer cells, and secreted IGFBP-1 inhibits AKT1-mediated phosphorylation of ser27 of mitochondrial superoxide dismutase 2 (SOD2), thereby increasing the activity of SOD2 antioxidant enzymes
NF-B, nuclear factor kappa-B
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