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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

It is a fundamentally different approach: instead of trying to force a large peptide through a hostile environment, Lilly designed a small molecule that activates the same receptor through a different structure

Phase 2 data up to 32 weeks showed an acceptable safety profile, but cardiovascular and renal outcomes over multiple years are not yet fully characterized

Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Atrial Fibrillation in Older Adults With Type 2 Diabetes