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The Phase 3 safety database for orforglipron, encompassing several thousand participants treated for up to 72 weeks, provides reasonable but not definitive reassurance regarding pancreatic safety
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Metformin The FDA also has a black box warning on metformin as it carries a serious safety risk of lactic acidosis
These reports had raised concerns that patients using these medications would have a much higher risk of pulmonary aspiration under anesthesia, which is a serious and potentially fatal complication. Dixit is the lead author of the study
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