Tissues rely on highly coordinated communication between cells, structural proteins and signalling molecules to maintain organisation and adapt to changing physiological conditions
This pattern is not like influenza, which usually causes a single epidemic wave (sometimes with more than one peak) each winter
The FDA recommends clinicians be well-informed when prescribing medications off-label
There are some data that acute COVID-19 infection is accompanied by signs of oxidative stress, including increased expression of ROS-response genes and glycolysis in peripheral blood mononuclear cells [72], increased MDA (TBARS assay), F-isoprostane, 8-hydroxy-2-deoxyguanosine, AOPP and nitrotyrosine levels, and lowered glutathione (GSH), -SH groups, selenium, zinc, TAC and vitamin D [49, 73,74,75,76,77,78,79]