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[3] [4] Significant weight loss, whilst therapeutically beneficial, could theoretically result in nutritional deficiencies if dietary intake is severely restricted or unbalanced
Indeed, GLUTag cells express the IL-6 receptor, and IL-6 treatment increases GLP-1 secretion in a dose-dependent manner, where acute IL-6 treatment increases GLP-1 exocytosis in a JAK2-STAT3-dependent manner, and chronic IL-6 treatment increases GLP-1 content and glucose uptake in a sodium glucose transporter 1-dependent manner in the L cell (Ellingsgaard et al., 2011)
Let's say you want a final concentration of 1 mg per 0.1 mL
These combined effects help increase satiety, reduce hunger, and promote a feeling of fullness
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