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Discussion The GLP-1-based therapies usually utilize two strategies: 1) inhibition of dipeptidyl peptidase 4 (DPP-4) enzyme with specific inhibitors, such as sitagliptin / vildgliptin, in order to raises plasma levels of endogenous GLP-1 and GIP and 2) utilizing DPP-4 resistant GLP-1 receptor agonists, such as liraglutide / exenatide 44

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