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Overall, the multimorbidity of depression and T2DM involves shared genetic risk factors and multiple underlying biological mechanisms, including HPA axis dysregulation, pro-inflammatory states, gut-brain axis interactions, and insulin signaling alterations, which can affect neurotransmission

Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care. Journal of Personalized Medicine , vol

The study followed 72 people whose body mass index made them overweight or obese who also met the clinical criteria for MDD, characterized by symptoms including depressed mood and loss of interest or pleasure in most activities

Y., Lee, C