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When the skin is infected or stimulated by ultraviolet radiation, NOX activity increases significantly, producing large amounts of superoxide anion (O 2 ) in the skin, which induces high cytotoxicity (Figure 1) (Nakai and Tsuruta, 2021)

Blood glucose levels were measured with EasyTouch blood glucose monitor (Wellmed EasyTouch GCU, ET-301 Multi-Function Monitoring System, Bioptik Technology Inc., Jhunan Township, TW) in all four meal schedule conditions according to the following timetable: immediately before administration of drug or vehicle (pre-treatment)

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The primary role of GPX3 was validated in primary cultured rat tenocytes treated with fluoroquinolone or H 2 O 2 , which accelerates senescence, in combination with dexamethasone or viral overexpression of GPX3