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Am J Surg Pathol 1989
Such changes are associated with impaired epithelial integrity, enhanced LPS-mediated immune activation, and downstream systemic and central inflammatory processes linked to dopaminergic neurodegeneration
Histopathology It can be seen under a microscope that large numbers of macrophages with rich pigment are deposited on the mucosal lamina propria, and a small number of neutrophils and granulocytes can be visualized at the same time
234,235 Future research should aim to develop integrative, multiomic panels that combine hormonal, lipidomic, and genetic markers to generate dynamic crosstalk signatures that are predictive of organ-specific and systemic complications
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