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Semaglutide 2.4 mg (Wegovy) received FDA approval for adolescents 12 and older in December 2022 [11]
Choosing based on your protocol When in doubt, stick with 3 mL
In the 1 mg trial arm, liver fat fell 51% among participants with fatty liver, visceral fat fell 16%, and triglycerides declined. Ketones are a separate matter: the same substudy found -hydroxybutyrate rose only at 4 mg and above, so the 1 mg arm does not carry a ketone signal in that population. Modeled metabolic-health protocols place heavier, metabolically average profiles near 1 mg weekly
Delayed approach: Add muscle preservation peptides after several months when muscle loss becomes apparent on body composition testing
