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Even people who achieve the treatment goals with the new obesity pharmacotherapies might decide to undergo bariatric surgery to support long-term weight maintenance because either they experience weight regain on the medication or they do not have long-term access to obesity pharmacotherapy, or they prefer not to take obesity pharmacotherapy lifelong
However, other studies have also reported that calorie restriction influences testosterone levels
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These predispositions do not determine outcomes but may help contextualize why some individuals experience more pronounced nausea, appetite suppression, or weight-loss responses during early treatment
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