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In vivo investigations were conducted through a randomized, double-blind, placebo-controlled clinical study that enrolled 21 healthy subjects

Dozens of FDA-approved estrogen, progesterone, and combination products exist in various strengths and delivery systems

Canonical GLP-1RAs, such as liraglutide, semaglutide, and tirzepatide (which possesses dual GLP-1/GIP receptor agonist activity), have consistently demonstrated superior metabolic and cardiorenal outcome benefits in large-scale randomized controlled trials (RCTs) (3538)

The authors emphasized the limitations of their findings, again with no proof that the drugs caused the problems