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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

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Non-alcoholic steatohepatitis (NASH) Excessive fat in the liver that has ignited inflammation and led to scarring in the liver

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The cause of epilepsy can be brain injury and other factors, but some reasons are unknown

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