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These vulnerabilities necessitate cryoprotectant strategies focused on DNA preservation, incorporating antioxidants such as GSH, vitamin E, polyphenols, seleno-organic molecules, and flavanoids which have been shown to mitigate cryo-induced genetic damage (152156)

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9 One randomized placebo-controlled trial that included 96 subjects greater than 70 years old and suffering from fatigue, most of whom also reported poor concentration or impaired memory, found treatment with 2 grams acetyl-L-carnitine twice daily for 180 days not only improved scores on a screening test of overall cognitive status (the MMSE), but also reduced mental and physical fatigue, fatigue after exercise, sleep problems, and muscle pain

10.1016/j.cmet.2008.07.005 35 SenguptaR.HolmgrenA