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Given a ~1hour half-life and hourslong systemic presence, a oncedaily or everyotherday regimen during any initial phase is typically pharmacokinetically reasonable
Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer
While effective, they require needles, refrigeration, and self-injection, which can be inconvenient or uncomfortable for some patients
Pending robust clinical evidence generation, a prudent individualized approach incorporating appropriate monitoring remains warranted
