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Besides, the rupture of the vessel wall in hemorrhagic stroke results in the accumulation and dissolution of iron-rich erythrocytes in the brain parenchyma and subsequent excessive presence of hemoglobin and heme iron in the extracellular environment, resulting in iron-induced lipid peroxidation and ferroptosis (DeGregorio-Rocasolano et al., 2019)

These young growing rats, which increased in body weight over the course of 42-days, exhibited a less pronounced weight gain and a resulting lower body weight at the end of the study when receiving daily semaglutide (41 10% weight gain) compared to a saline control (65 13% weight gain) ( P = 0.0114, Table S6)

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