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GLP-1RA did not decrease the rate of hypoglycemic events in the pooled effect size ( OR 0.60

Arterial stiffness is more prevalent in older individuals [104] and occurs naturally with aging as a consequence of fragmentation and degradation of elastin in the wall of the aorta and its replacement with much stiffer collagen fibers [105]

Mediation analysis demonstrated that 82.8% of steatosis improvement, 71.6% of ballooning reduction, and 69.3% of MASH resolution were attributed to weight loss, while only 25.1% of the fibrosis benefit was weight-related, indicating that other mechanisms other than weight loss may also play a role in the histological improvements associated with semaglutide

Athletes and outdoor workers can sweat 13 liters per hour during intense effort in heat, which makes a 24-hour window realistic regardless of starting hydration