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Given that oxidative damage and chronic inflammation are hallmarks of aging, diet-derived antioxidants including melatonin itself could play a pivotal role in promoting healthy aging via maintenance of circadian system integrity (Moroan et al., 2022
This response can be explained by the significant role of Met in the mTOR pathway, as Met consistently appears as the most limiting amino acid affecting milk protein synthesis in dairy cows
Its pharmacokinetic profile shows rapid distribution with peak serum concentrations occurring 3060 min post intravenous administration [10]
Hence, the impairment of mitochondrial function by genetic, environmental, or age-related factors has broad implications in human disease, including neurodegenerative, cardiovascular and metabolic diseases, as well as cancer and ageing 1,2
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