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In reversed-phase HPLC (RP-HPLC), the peptide mixture is separated based on hydrophobicity as it passes through a C18 or C8 column

There were no language or time restrictions on the search, but we focused on articles published in the past 20 years to ensure the relevance and timeliness of the information

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Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]