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In the Common Data Model framework, the diagnosis date reflects the time a diagnosis is first recorded in the medical record, which may not represent the true onset of symptoms

Understanding the distinct and complementary contributions of each receptor system is essential to appreciating how mono-, dual-, and triple agonist formulations achieve their therapeutic effects [7-9,18,19] [Figure 1 and Table 1]

Importantly, these medications carry a boxed warning and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Unlike other chronic diseases, meaningful changes in body weight are visible to the naked eye