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The receptor overlap would create unpredictable dose-response relationships and increase the risk of severe GI side effects

She expands, sharing: Theres an autoimmune spectrum and depending on how much inflammation your body has at any given time, you can move up or down that spectrum. Functional medicine is about reducing inflammation to shrink or even cause symptoms to disappear

Randomization to either active treatment or placebo was double-blinded, but assignment across doses was not blinded, because of differences in treatment volume

NSAIDs, including ibuprofen, have been associated with small increases in cardiovascular risk, particularly with high doses or prolonged use