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A recent study from the University of Pennsylvania found that intermittent use of GLP-1 drugs could actually have the opposite effect of what users intend

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Proof-of-principle evidence was provided that FXR1 antagonism could alleviate bone metastasis of ER+ breast cancer cells with acquired anti-estrogen resistance, wherein PI3K/AKT/mTOR signaling is often abnormally activated ( Statements Data availability statement The datasets presented in this study can be found in online repositories