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3.3 Metformin inhibits the succinate-GPR91 pathway Succinate is an intermediate product of the tricarboxylic acid cycle, which can be converted into fumaric acid by succinate dehydrogenase
Weghuber D, Barrett T, Barrientos-Perez M, et al
"FDA approves Novo Nordisk's oral semaglutide for cardiovascular (CV) risk reduction in adults with type 2 diabetes who are at high risk, including those who have not had a prior CV event" (Press release)
