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Targeting these molecules with neutralizing antibodies or small-molecule antagonists (e.g., glycyrrhizin) has demonstrated BBB-stabilizing effects in vivo , including reductions in brain edema and vascular permeability (Lochhead et al., 2020
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In parallel, integrated analyses of pyroptosis-related differentially expressed genes have identified a ten-hub-gene signature that is intimately linked with the upregulation of pro-inflammatory M1 macrophage infiltration in human DKD renal tissues (233)
Molecules (Basel, Switzerland), 28(24), 8038
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