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In male rats exposed to alcohol for long periods of time, acute treatment with either Ex-4, GLP-1, liraglutide or semaglutide reduces both the alcohol consumption and the preference for alcohol ( Taken together these preclinical studies show that GLP-1R activation is required for alcohol consumption, an effect persistent across species and GLP-1R agonists used

The other lipid metabolism-related genes, including HAD, ACOX3, CD36, ATGL and HSL , remained unchanged in the livers and muscles of the two groups in the two states

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