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Its unique ability to cross the blood-brain barrier enhances memory, focus, and cognition
Polymyxins are antimicrobial peptides that interact with the lipopolysaccharide (LPS) moiety of the membrane of Gram-negative bacteria and induce divalent cation displacement, resulting in destabilization of the membrane, loss of integrity, and cell death 3,4,5
Providers who push faster titration may get patients to therapeutic doses sooner, but they also lose more patients to intolerable side effects
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