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The consistency between TRIUMPH-4 and TRIUMPH-1 two different populations, different trial durations, nearly identical results is strong evidence that retatrutide's efficacy is reproducible in general obesity populations
When evaluating the ADC, only the semaglutide group had a significant change compared with placebo, with a reduction from 0.1910 3 mm 2 /s (95% CI 0.16, 0.23) at baseline to 0.0810 3 mm 2 /s (95% CI 0.01, 0.14) at 32 weeks ( p =0.01) (corresponding to a reduction of 63%) (Fig
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