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The presence of a cysteine at the active site is essential for the catalytic functioning of DHAR, as mutation of this cysteine abolishes the activity

However, no completed trial has examined the effect of GLP-1 RAs on cardiovascular events in patients with established CVD and overweight/obesity in the absence of type 2 diabetes

These experiments should aim to use human pancreatic endothelial cells from T1D donors and autoreactive CD8+ T cells to perform in vitro transwell-based extravasation assays