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Deficiency of Trem2 in macrophages worsens lipid accumulation and ferroptosis in TECs via IL-1-dependent CD36 upregulation, thus promoting DKD progression (201)

It also offers the potential to transiently alleviate cellular oxidative stress associated with aging and most poor health conditions, giving cells an opportunity to recover and improve physiological function

Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)