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When tested in obese mice and musk shrews, TDN helped the animals lose weight and respond better to insulin without causing nausea or vomiting
Materials and methods Animals Wild type (WT) BALB/cJ, recombination-activating gene 2deficient [Rag2 / , C.B6(Cg)-Rag2tm1.1Cgn/J, RRID: IMSR_JAX:008448], and Rag2-deficient chaindeficient (Rag2 / GC / , C;129S4-Rag2tm1.1FlvIl2rgtm1.1Flv/J, RRID: IMSR_JAX:014593) mice were obtained from The Jackson Laboratory
Carnitine and its derivatives in cardiovascular disease 31
For the studies including assessments at multiple time-points, the data at baseline and immediately after the weight loss phase were extracted for the analysis
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