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Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo
Toki S, Newcomb DC, Printz RL, Cahill KN, Boyd KL, Niswender KD, et al
Collectively, these findings position glutathione at the convergence of oxidative stress regulation, mitochondrial function, vascular integrity, and cardiometabolic balance
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