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In order to determine if compounds showed selective inhibition of TGR compared to human TrxR and GR, the IC 50 values for TGR were compared to those of human TrxR and GR either reported in literature or determined here (Table 4)
Moreover, in STEP 8 [46], semaglutide 2.4 mg exhibited superior efficacy compared with liraglutide 3.0 mg, achieving a mean reduction in BW of more than 10%
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Tan, who was not involved in the orforglipron trials
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