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In particular, the improvement of therapeutic half-life 5 through incorporation of non-natural amino acids, D-amino acids, PEGylation, N- and C-terminal modifications, and attachment on the side chains has afforded an extended therapeutic window of activity in vivo , leading to dosing regimens that are comparable to those of small molecules
Among these, the DIO2 Thr92 Ala (rs225014) is one of the most extensively studied single nucleotide polymorphisms (SNPs) [104]
The safety margin sits approximately 300-fold above therapeutic doses, making GHK-Cu one of the most well-tolerated peptides available for research purposes
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