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Circulating MOTS-c levels are lower in older adults, lower in people with insulin resistance, and rise acutely in response to high-intensity exercise [2]
Patients with chronic liver disease caused by viral hepatitis (positive serology for hepatitis B or C), excessive alcohol consumption, other causes of chronic liver disease (such as autoimmune hepatitis or hemochromatosis), and those using hepatotoxic drugsincluding glucocorticoids, methotrexate, antiretrovirals, amiodarone, tamoxifen, or estrogenswere excluded
Nutr Rev 2002;60:1424
Given its effects on appetite, nutrition, and metabolism, use during these periods is not recommended
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