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The interplay between ferroptosis and other mechanisms in these diseases requires further research to determine the optimal strategies for targeting ferroptosis in therapy (265)

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Furthermore, current immunomodulatory therapies, including immunosuppressants and biologics, remain predominantly palliative

Therefore, increased nutrient influx for these commensal bacteria coupled with decreased acid secretion, barrier breakdown, and alteration of the intestinal adaptive immune system would lead to proliferation of these bacteria, resulting in the occurrence of small intestinal bacterial overgrowth (SIBO) and the development of food intolerances [294, 295]