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Peripheral and Autonomic Nerve Symptoms The combination of Benfotiamine, R-Lipoic Acid, and active B vitamins makes this formula particularly suited for addressing the painful and disruptive symptoms of peripheral and autonomic neuropathy: Burning, Tingling, and Numbness (Neuropathy): Benfotiamine blocks the accumulation of toxic metabolic byproducts (AGEs) in the nerves, while R-Lipoic Acid reduces localized oxidative stress, helping to alleviate the painful "pins and needles" sensations in the hands and feet