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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day)
Lindemann, A
doi:10.1001/jamaoncol.2015.0137
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