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For a long time, the manifestation of depressive symptoms has been also associated with the deficits in neurotrophic factor action in the brain [51], especially highlighting the role of diminished brain-derived neurotrophic factor (BDNF) signaling as important for the pathogenesis of this mental disorder [52]
doi: 10.3390/jof6010021 56 NettJ
Simultaneously, it downregulates pro-inflammatory and fibrotic pathways, which are often implicated in aging and tissue damage
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