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GLP-1R is expressed in dorsal root ganglion (DRG) neurons 40 and could explain the potential direct effect on pain in OA since DRG neuron endings are present in the synovium 41
For the purposes of this guide, it is ESTIMATED that compounded sublingual administration using SubMagna HMW achieves 10% systemic absorption
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They are stacking it with other supplements, combining it with dietary changes, or in some cases, taking it alongside GLP-1 medications
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