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Summary Keywords Bayesian network meta-analysis, fertility management, GLP-1 receptor agonists, Polycystic Ovary Syndrome, preconception care, reproductive safety, washout period, weight loss Citation Song E, Fang Y, Li X, Fu W, He H, Gao Z, Tian X and Gao B (2026) Balancing metabolic optimization and reproductive safety in Polycystic Ovary Syndrome: a Bayesian-informed framework for GLP-1 receptor agonists