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Leptin is secreted by adipose tissue and binds to leptin receptors on hypothalamic neurons, inhibiting orexigenic neurons and activating anorexigenic neurons
This mechanism is relevant to neuropathy because NF-kB-driven inflammation is a central mediator of nerve damage in diabetic neuropathy, autoimmune neuropathies, and chemotherapy-induced peripheral neuropathy
Double Trouble: Low B12 + Low D3 When both are low, the risk is higher because: Blood vessels get damaged
Improvement is progressive and cumulative skin continues to improve over months of regular use
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