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Notably, RT-qPCR analysis showed a sharp increase in OCT4 mRNA expression, a marker of pluripotent stem cells and essential for TIC self-renewal [33], in the colonies formed in 3D gels relative to 2D culture conditions (Fig
HIF-1 pathway is not only responsible for the regulation of osteogenesis and osteoclastogenesis, but also for the coupling of the two processes [50,51,52]
Channels created by microneedling begin closing within minutes
However, researchers believe that more large-scale studies are needed to fully prove these initial positive results
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