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When AMP binds to the subunit, it allosterically activates the complex, making it a more susceptible substrate for phosphorylation at the threonine 172 site, which is more easily phosphorylated in the activation loop of the subunit by the primary upstream AMPK kinase LKB1
Pravat K Mandal, Anshika Goel, Ashley I Bush, Khushboo Punjabi, Shallu Joon, Ritwick Mishra, Manjari Tripathi, Arun Garg, Natasha K Kumar, Pooja Sharma, Deepika Shukla, Scott Jonathan Ayton, Amir Fazlollahi, Joseph C Maroon, Divya Dwivedi, Avantika Samkaria, Kanika Sandal, Kanu Megha, Sandhya Shandilya, Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimers disease compared with healthy elderly participants, Brain Communications, Volume 4, Issue 5, 2022, fcac215, Watanabe F, Hashizume E, Chan GP, Kamimura A
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