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Pros: Can be taken without food and water restrictions and therefore suitable for those with busy or unpredictable schedules Convenient once-daily pill lowers A1C by an average of 1.3% to 1.6% from a baseline of 8.0%, compared to placebo at 40 weeks in the ACHIEVE-1 trial Significant weight loss results in the ACHIEVE-1 trial, where participants taking orforglipron lost an average of 16.0 lbs (7.9%) at the highest dose

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