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The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-/, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH)
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In this context, interest has emerged in incretin receptor agonists as potential modulators of pulmonary fibrotic pathways, although the supporting evidence remains preliminary
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