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The 25.4-fold increase in collagen IV when combined with hyaluronic acid indicates significant structural improvement potential
Subcutaneous injection is also used in some research protocols
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The opposing effects of cannabinoids (either improving or worsening intestinal permeability) might be related to the recent observation that endocannabinoids such as anandamide worsen permeability while phytocannabinoids like cannabidiol and tetrahydrocannabidiol, which might act as (partial) CB1R antagonists, promote protection or recovery from intestinal permeability [52]
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